Oleuropein as an inhibitor of peroxisome proliferator-activated receptor gamma

Role of peroxisome proliferator-activated receptor alpha and gamma in antiangiogenic effect of pomegranate peel extract

Objective(s): Herbal medicines are promising cancer preventive candidates. It has been shown that Punica granatum L. could inhibit angiogenesis and tumor invasion. In this study, we investigated whether the anti-angiogenic effect of pomegranate peel extract (PPE) is partly attributable to Peroxisome proliferator-activated receptors (PPARs) activation in the Human Umbilical Vein Endothelial Cell...

PPARG ( peroxisome proliferator - activated receptor gamma )

Note: The PPAR gamma gene, a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear hormone receptors, is implicated in adipocyte differentiation and function. In order to regulate the transcription of target genes, the PPAR protein needs to form heterodimers with retinoid X receptors (RXRs). Three splice variants of PPAR gamma are known: PPAR gamma1, PPAR gamma2, ...

Peroxisome proliferator-activated receptor gamma in osteoarthritis.

Osteoarthritis (OA) is among the most prevalent chronic human health disorders and the most common form of arthritis. It is a leading cause of disability in developed countries. This disease is characterized by cartilage deterioration, synovitis, and remodeling of the subchondral bone. There is not yet a satisfactory treatment to stop or arrest this disease process. Although several candidates ...

تعیین پلی‌مورفیسم ژن Peroxisome proliferator-activated receptor-gamma در بیماران مبتلا به عفونت با هلیکوباکتر پیلوری

  سابقه و هدف: پروتئین (PPAR g ) Peroxisome proliferator-activated receptor-gamma یک فاکتور رونویسی وابسته به لیگاند است که در فرایند بیماری‌های مختلف از جمله فرایندهای التهابی و سرطان دخیل است. هدف از این پژوهش بررسی پلی‌مورفیسم ژن PPAR g و ارتباط آن با عفونت هلیکوباکتر پیلوری و بیماری‌های دستگاه گوارش در بیماران بود.   مواد و روش ‌ ها: در این بررسی 200 بیمار مبتلا به هلیکوباکتر پیلوری وارد مط...

Peroxisome Proliferator-Activated Receptor